Drinking alcohol 6 hours after taking amoxicillin usually has no effect, but it is not recommended. Clinically amoxicillin belongs to penicillin antibiotics, generally for Streptococcus pneumoniae, hemolytic streptococcus has a better therapeutic effect. Usually after oral administration, the peak blood concentration can be reached in about 1 hour, and then it has a therapeutic effect. The drug is excreted in the urine or from the biliary tract in about 6 hours. Therefore, drinking alcohol within 6 hours of taking amoxicillin will not affect the human body and will not cause disulfiram-like reactions. Drinking alcohol while taking amoxicillin is usually not recommended because the body’s metabolic function is weaker during the illness and the immune system is weaker. Drinking alcohol into the gastrointestinal tract will cause gastric mucosal irritation, resulting in abdominal pain, nausea, vomiting and other discomforts. At the same time, it may also lead to liver function damage, which is not conducive to the health of the body. If any discomfort occurs after drinking alcohol while taking amoxicillin treatment, it is recommended to consult a doctor promptly.