Anogenital condyloma acuminata (CA) is a sexually transmitted disease caused by human papillomavirus infection. Human papillomavirus infection of the anogenital epidermal cells can manifest as warts that are visible to the naked eye (clinical infection) as well as subclinical infections that are not visible to the naked eye. Traditional treatments for anogenital warts are varied and include topical medications (e.g., gonadotoxin, miquimod, trichloroacetic acid, etc.), surgical or destructive treatments (e.g., freezing, CO2 laser, surgical excision, etc.). However, all of these methods can only remove warts that are visible to the naked eye, and latent HPV infection may persist and become a source of recurrence and transmission. Topical topical aminoketovaleric acid (ALA) combined with photodynamic therapy (PDT) is a non-invasive treatment for proliferative disease. The main mechanism of ALA-PDT is that aminoglutaric acid is taken up by proliferating cells and converted into large amounts of porphyrin IX that accumulate in these cells. Since epidermal cells infected with HPV are in an active proliferative state and epidermal cells not infected with HPV are in a normal metabolic state, ALA-PDT selectively kills HPV-infected epidermal cells (including warts visible to the naked eye and cells not visible to the naked eye), while leaving epidermal cells not infected with HPV undamaged. This is the reason why this method has a lower recurrence rate and fewer side effects compared to conventional treatments.