Osteosarcoma is a malignant tumor of bone tissue that can occur at any age, but it is common in adolescents and more common in males. The tumor is usually located at one end of the long tubular bone, such as the proximal femur, distal femur, and proximal tibia. The main symptom of osteosarcoma patients is local pain, which is persistent and gradually increasing, and the pain is more obvious at night. As the tumor grows, the skin temperature of the tumor surface increases and the veins become angry. Osteolytic osteosarcoma can have pathological fracture due to external force. The diagnosis of osteosarcoma depends mainly on clinical manifestations, X-ray and pathological examination, but finally it depends on pathological biopsy to determine. Usually, 80% of osteosarcoma is diagnosed with lung metastasis. Comprehensive treatment, mainly surgery, is the main method of treatment for this disease. Neoadjuvant chemotherapy combined with postoperative chemotherapy has greatly improved the 5-year survival rate of the disease. For patients with indications for limb preservation, limb preservation surgery with scientific and reasonable chemotherapy regimen not only prolongs the survival period of patients, but also greatly improves their quality of life. If you are considering or have been diagnosed with osteosarcoma, you must go to a qualified and regular hospital for treatment, and do not use methods such as external Chinese medicine, as this will accelerate the growth and distant metastasis of the tumor and make standardized treatment difficult.