Staphylococcus saprophyticus sepsis requires the selection of appropriate drugs based on drug sensitivity tests, and commonly used drugs are linezolid, vancomycin and so on. Staphylococcal septicemia is an infectious disease in which staphylococcus bacteria invade the circulatory system and multiply to produce large amounts of toxins in the circulatory system, thus causing systemic infection. Staphylococcal septicemia, may have high fever, chills and other symptoms, is a serious systemic infection, the onset of disease is acute, serious, easy to form migratory foci. Therefore, once diagnosed with staphylococcal sepsis in the early stages, it is important to conduct drug sensitivity tests to select the appropriate drugs for antimicrobial treatment, such as linezolid, vancomycin and so on. These drugs can quickly kill staphylococci, thus controlling the development of the disease. Along with treatment, attention should also be paid to nutritional supplementation and electrolyte balance to prevent complications. It is recommended that the specific use of drugs for putrefactive staphylococcal sepsis, to the regular hospital to use drugs according to the doctor’s instructions.