Chronic severe hepatitis B virus hepatitis can make the patient’s symptoms better through treatment, but cannot make the disease completely cured. For chronic severe hepatitis caused by hepatitis B virus infection, generally through entecavir, tenofovir and other anti-hepatitis B virus treatment can control the patient’s condition to a certain extent, reduce the hepatitis B virus load in the body, so as to reduce the reproduction of hepatitis B virus and damage to liver cells. After standardized treatment, the condition of patients will improve significantly and reach clinical stability, but the current treatment cannot completely eliminate hepatitis B virus, and regular testing of viral load and review of liver function are needed after infection with hepatitis B virus. Therefore, patients with chronic severe hepatitis B virus hepatitis should go to the hospital in time, under the guidance of doctors to standardize the treatment, and after the control of the disease should follow the doctor’s instructions for follow-up and treatment.