Serous urticaria is mostly caused by the injection of foreign body serum and foreign substances of animal origin. Most of the serous urticaria is caused by some systemic symptoms such as poor appetite, general malaise, headache and fever within a few hours to one or two days after the appearance of rubella masses, and the symptoms of serous urticaria are self-limiting and can gradually disappear, but there can be a few severe symptoms causing death. For the treatment of serous urticaria, it is currently believed that the most important thing is to avoid triggering factors, for example, if certain drugs are triggered, attention should be paid to avoiding these drugs from use. In addition, serous urticaria can be treated with appropriate anti-allergy medications, such as the antihistamine Benadryl. In addition, for more severe serous urticaria, glucocorticoids may be required if life-threatening conditions arise.