I. Joint symptoms: 1. Morning stiffness: the first symptom of the joint, often appearing before the joint pain. Joint stiffness starts with pain and discomfort when moving, and morning stiffness is reduced or disappears when joint activity increases. Morning stiffness of the joint is obvious in the morning and reduced in the afternoon. 2. Swollen and painful joints: Mostly symmetrical, often affecting metacarpophalangeal joints, wrist joints, shoulder joints, interphalangeal joints, ankle joints and knee joints. The joints are red, swollen, hot, painful, and have impaired movement. Extra-articular manifestations: It is part of the systemic manifestations of rheumatoid arthritis or its complications. The joint lesions of this disease can be disabling, but not fatal. The extra-articular manifestations are often the cause of death in this disease. 1, rheumatoid nodules: seen in 15-20% of patients, mostly on the extensor side of the forearm where pressure is often applied, such as the ulnar side and the hawk’s beak. Soft amorphous active nodules or rubber-like nodules fixed in the periosteum are felt under the skin. The subcutaneous rheumatoid nodules are more common in those with strong positive serum rheumatoid factor. 2, rheumatoid vasculitis: rheumatoid vasculitis is the basic lesion of the disease, in addition to joints and peri-articular tissue, vasculitis can occur elsewhere in the body. The manifestation is distal vasculitis, skin ulcers, peripheral neuropathy, pericarditis, visceral arteritis such as heart, lung, intestine, spleen, pancreas, kidney, lymph nodes and testes, etc. 3, rheumatoid heart disease: heart involvement, myocardial, valvular ring or aortic root rheumatoid granuloma formation, or myocardial, endocardial and valvular ring lymphocyte infiltration or fibrosis, etc. 4, rheumatoid lung disease: chronic fibrous pneumonia is more common, with fibrin-like necrosis and mononuclear cell infiltration of small blood vessels in the lungs, fever, dyspnea, cough and chest pain. 5, kidney damage. 6, eye manifestations: uveitis is a common lesion of juvenile rheumatoid arthritis, adult human rheumatoid arthritis often causes keratitis. 7, Felty syndrome: is a severe rheumatoid arthritis, often causing splenomegaly, neutropenia, high rate of positive serum rheumatoid factor, anti-nuclear antibody positive. 8.Dry syndrome: It is a chronic inflammatory autoimmune disease. It mainly invades the lacrimal gland and large and small salivary glands, etc., resulting in glandular destruction and reduced secretion or lack of it, with clinical manifestations of dryness syndrome mainly in the eye and oral mucosa. 9.Digestive tract damage.