When a patient has symptoms of itching between the anus and the testicles, first, it is considered that it may be due to the fact that the patient usually does not pay attention to the hygiene and cleanliness of the perineum, and the lack of diligent change of underwear leads to a large amount of dirt remaining in the perineum, and the local itching will occur under the stimulation of the dirt. Secondly, it may be due to a bacterial or viral infection that leads to the appearance of epidermolysis bullosa, which can also cause itching symptoms. Again, it may also be due to the presence of allergies to the underwear worn by the patient, and localized itching may occur due to the irritation of the allergen on the skin. It is recommended that patients who experience itching between the anus and the testicles must seek medical attention in a timely manner to deal with the different causes of the problem. Finally, if the itching is caused by bacterial, fungal or viral infections, you can apply Bactrim ointment, Dacronin ointment or Aciclovir ointment for treatment. If you are allergic to underwear, you should change your underwear in time to effectively avoid itching caused by allergies.