Multiple myeloma is a common disease in the hematopoietic system. Due to the proliferation of myeloma cells in the bone marrow, myeloma cells secrete substances that promote osteoclast activity, resulting in osteoporosis and even fractures (also known as pathological fractures, meaning that patients experience fractures under the action of minor external forces, mainly seen in the spine and ribs), and patients experience symptoms such as back pain and chest pain. Due to osteoporosis, patients bone often buy some calcium tablets to supplement calcium, thinking that this can make bones strong. Indeed, myeloma has a serious calcium deficiency in the body, and doctors often have to give patients calcium supplementation therapy during treatment. However, the main cause of osteoporosis in myeloma patients is not the lack of calcium intake, but the increase in calcium decomposition due to the increased activity of osteoclasts, which causes an increase in calcium in the serum, which can cause hypercalcemia in severe cases, and the patient develops coma, kidney failure and other symptoms, requiring emergency treatment. This condition usually occurs during the active phase of the disease. Therefore, calcium should not be supplemented before the disease is under control. After the disease is stabilized, calcium can be supplemented under the guidance of a doctor, and during the process of calcium supplementation, myeloma-related indicators should be tested regularly, and the medication should be stopped in time when the disease is active. Meanwhile, bisphosphonates (Eppen, disodium pamiphosphate, etc.) can promote the deposition of calcium in bones. Patients with myeloma are recommended to have regular infusion of the above drugs.