Many family members of myeloma patients consult the patient’s care, ask the nurse and review some literature summarized as follows: 1. Pain care Patients are forced to position, the patient feels that the low back, thorax and limb bone wandering bone pain is progressively aggravated, especially when the physical activity pain is intense, the patient constantly moaning, pain face. At this time, we give care, consideration and comfort to the patient, explain the cause of pain to the patient, and give painkillers as prescribed by the doctor, so that timely and effective pain relief is essential, but we must choose a good time, dose and route of administration, so that the drug can maintain a certain concentration level of the drug in the body and achieve long-term and effective analgesic effect. On the contrary, if the drug is given arbitrarily, it will not only fail to achieve pain relief, but also produce drug resistance, which will affect the treatment. After drug administration, the pain relief effect can be closely observed, and non-pharmacological measures can also be used to relieve pain, adopt relaxation techniques, distract the patient’s attention, ask the patient to do more deep breathing exercises, listen to music, read books, tell stories, watch TV, communicate more to divert the patient’s attention, massage the patient’s lesions appropriately to reduce muscle tension, and also promote blood circulation. Give the patient a comfortable position, reduce noise and light, appropriate temperature and humidity to make the patient comfortable, and ensure enough time for rest and sleep. Pain can also be controlled by relaxation, biofeedback method, peripheral nerve block, acupuncture and other methods. 2. Somatic mobility disorder Patients are paralyzed due to osteoporosis, destructive compression of thoracolumbar spine and compression of bone marrow. Patients adopt passive position and must do a good job in life care, assisting patients in washing, eating, urinating and defecating, personal hygiene, and contacting friends and family by phone. Assist the patient to change position every 1 to 2 hours, keep the patient’s limbs in a functional position, closely observe the pressure on the limbs, prevent atrophy of the limbs, give limb massage, exercise the passive and active activities of the limbs, most importantly, skin care, long-term bed rest, establish a skin care bed head card, every time you turn over, record the bed head card by time, and record the skin condition in the handover book, in order to prevent pathological fractures, active bone pain, turn at least 3 people with even strength and consistent pacing to maintain the patient’s balance position. At the bony prominence, pad the air ring or valley whisky, hollow pillow, scrub the whole body with warm water every day, change the sick clothes and bed sheets in time, keep the bed flat and free of stains, keep the skin clean, and prevent the occurrence of decubitus ulcers. 3.Prevent infection Patients who are bedridden for a long time are prone to pneumonia, give back pat and change the lying position. Advise patients to breathe deeply, keep fresh air in the room, open the window twice a day for 15-20 minutes each time, wipe the ground and bed units with 84 disinfectant, change bedheads, uniforms and hospital clothes regularly, so that they are not easily damp and kept clean, instruct patients to maintain good living habits, assist patients to wash hands and rinse their mouths before and after meals and before going to bed at night. Teach patients not to pick their nostrils, not to scratch, to cut their nails regularly and to wash their hair every week. Nurses wear masks before and after operation, reduce visits, especially do not contact with patients suffering from colds. 4. Oral care Do oral care after 3 meals daily, remove food residues in the mouth and prevent oral infection. 5.Fever care Give physical cooling, warm water bath. Ask them to drink more water and give anti-inflammatory pain suppositories if necessary. 6. Fracture care Splinting and observation of good peripheral blood flow and no local rupture, and instruct them to move appropriately. To prevent fracture, the patient should sleep on a hard board bed and avoid using elastic bed. 7. Defecation care Long-term bed rest, slow gastrointestinal peristalsis, bed defecation is not adapted, defecation is more difficult, so it is necessary to defecate regularly and maintain good defecation habits. Ensure sufficient daily water, fruits, vegetables and foods with high fiber content, give stool softeners if necessary, and use acupressure and pressure methods can relieve the patient’s constipation. (1) massage method: patient supine position, abdomen relaxed, left hand on the bottom, right hand on the top, placed under the right small abdomen, with the size of the fissure muscle and palm root force, along the ascending colon, transverse colon, descending colon, sigmoid colon direction to repeatedly push out the massage, so that the abdomen down about 1cm, the amplitude from small to large, until the intestinal peristalsis, once a day, each time 10-15 minutes, in the daily 30 minutes after breakfast or before defecation 20 minutes before defecation. (2) Acupressure: The patient is placed in the recumbent position and performed 10 minutes before the daily bowel movement. The Tianshu point (located 2 inches from the umbilicus) is pressed with the thumbs of both hands, from light to heavy, gradually increasing the force, with soreness, pain and intestinal peristalsis after 3 to 5 minutes, each press lasting from a few seconds to 1 minute. Zhi Gou point (located in the wrist bone 3 inches on the transverse stripe), between the ulna and radius, the same technique as above, after 3 to 5 minutes can be effective, such as a pressure effect is not good, you can repeatedly alternate pressure, until defecation. 8, psychological care Patients are bedridden for a long time, being tortured, anxiety, insomnia, depression, irritability, loneliness, fear of being discarded by the family. In this regard, medical and nursing staff take the initiative to contact with patients, doubling their love and care, eliminating the sense of strangeness and loneliness, often communicating with patients, understanding their psychological state, understanding their needs, helping them solve their difficulties, and establishing a good nurse-patient relationship with patients. Facilitate patients to voice their worries and pains, use kind words, expressions and behaviors to influence change patients’ mental stress, and seek practical and effective ways to talk, accompany memories, etc. Make the patient face the reality, get rid of the fear, emotionally stable, build up the patient’s confidence to overcome the disease, seek the cooperation of the patient’s family and relatives and friends, guide and encourage them to take the initiative to participate in clinical care work, help the patient to really solve the problems, such as physical, family, economic and other aspects that bring troubles and anxiety.