How to rule out that you have leukemia needs to be determined based on several aspects such as FAB typing criteria, immunological tests, and genetic blood assay tests for leukemia. In addition to the tests, it is also necessary to analyze the leukemia according to the symptoms that appear, and when it is diagnosed as leukemia, it needs to be admitted to hospital for active treatment.1. FAB typing criteria: FAB typing is currently a more widely used criterion for the diagnosis of leukemia, based mainly on the morphological and cytochemical characteristics of human bone marrow cells, stipulating that primitive cells > 30% are the diagnostic criteria for leukemia, and dividing acute leukemia The division into acute lymphocytic leukemia and acute non-lymphoblastic leukemia; 2. Immunological examination: cellular immunological examination mainly takes flow cytology to analyze the immunophenotyping of leukemia cells, and bone marrow cells are taken from the body of the subject, which can be divided into lymphocytes, monocytes, mature granulocytes, etc. The antigens contained in non-normal cells can be easily identified through the test; 3. Genetic determination : Genetic determination is mainly based on cytogenetic karyotype analysis, most leukemias have chromosomal aberrations such as gene deletions, duplications, and ectopics, chromosomal aberrations will involve more fusion genes for most purposes, there are various types of fusion genes associated with leukemia, common fusion genes are BCR-ABL, AML1-ETO, PML-RARa, etc.; 4. Clinical manifestations The first symptoms of leukemia when it occurs are fever, infection, progressive anemia, significant bleeding tendency or bone and joint pain, and a few people may develop convulsions, toothache, and systemic infection after the disease gradually progresses. In addition to the above FAB typing criteria, immunological tests, genetic measurements and clinical manifestations, a combination of bone marrow aspiration and smear examination of bone marrow fluid is required to confirm the diagnosis of leukemia.