Middle and low differentiated bile duct adenocarcinoma is serious. This is because middle and low differentiated bile duct adenocarcinoma is a highly malignant tumor with poor prognosis. According to the degree of differentiation, tumors can be divided into three levels: low, medium and high; the higher the degree of differentiation, the lower the degree of malignancy, which belongs to low and medium differentiated bile duct adenocarcinoma which is a malignant tumor of medium or above degree of malignancy. Although the degree of malignancy of middle and low differentiated bile duct adenocarcinoma is higher, if it is found in early stage and treated actively in early stage, the tumor can be removed by surgery, and sent to pathological biopsy after surgery, with radiotherapy and chemotherapy, which is of great significance for prolonging the life of the patients and improving the quality of life of the patients. For patients with low or middle differentiated bile adenocarcinoma, they should keep their moods relaxed, eat foods rich in vitamins and proteins, avoid greasy, spicy and stimulating foods, take reasonable rest, avoid staying up late, and go to the hospital in time if they have any discomforts, so as not to be careless and delay the treatment.