Aplastic anemia (hereinafter referred to as “reblast”) is a malignant and common blood disease, especially acute reblast, with rapid onset and critical condition, and most of them die within a year if left untreated or treated only with general treatment. But you may not know, a dozen years ago drops of chloramphenicol eye drops, a dozen years later may trigger aplastic anemia! Then what factors in life can cause aplastic anemia after long-term exposure? A, chloramphenicol, sulfonamide may induce reoccurrence Drugs are the more common factors in the development of aplastic anemia. There are two types of drug-induced reoccurrence: the first type is related to the dose of drugs, which is the effect of drug toxicity, and will cause myelosuppression at a certain dose, which will occur in all drug users and is generally reversible, such as various antineoplastic drugs such as erythromycin, cyclophosphamide, cytarabine, methotrexate, etc. The second category has little to do with drug dose and is related to individual sensitivity. Only individual patients with hematopoietic disorders occur among those who use the drugs, mostly due to allergic reactions to the drugs, which often lead to persistent reoccurrence. There is a wide variety of drugs in this category, and the common ones are chloramphenicol antibiotics, antipyretic and analgesic drugs (such as aminopyrine and pautazone), sulfonamides, antithyroid drugs (such as tabazol and methylphenidate), antituberculosis drugs (such as isoniazid), anthelmintics, insecticides, etc. It is common to see patients with remittent disease after the use of chloramphenicol, antithyroids or antituberculosis drugs in clinical sessions. Among them, it is particularly worth to raise chloramphenicol as the most common etiology of drug-induced reoccurrence, which is related to the abuse of this drug. According to a domestic survey, the risk of reoccurrence for those who used chloramphenicol within six months was 33 times higher than that of the control group. The risk is even greater if the drug is not taken as prescribed, if the drug is purchased on its own and abused, or if the blood count is not monitored regularly when necessary. Avoid drugs such as chloramphenicol and sulfonamides that may affect the hematopoietic system to reduce the chance of developing the disease. Never buy or take medications without a doctor’s prescription. When taking drugs that may cause reoccurrence, regular blood tests should be conducted and the drugs should be stopped if necessary. Among the factors that may trigger reoccurrence, there is another one that is very close to us – viral hepatitis, including hepatitis B and C. The relationship between viral hepatitis and reoccurrence has been more certain and is called viral hepatitis-related reoccurrence, and clinically we can see cases of aplastic anemia related to hepatitis B, accounting for 3.2% of patients with reoccurrence. 3.2% of patients with aplastic anemia. Hepatitis virus has a direct inhibitory effect on hematopoietic stem cells and can also cause chromosomal aberrations and autoimmune abnormalities mediated by the virus. Viral infection can also destroy the bone marrow hematopoietic microenvironment. To actively prevent and treat hepatitis, pay attention to the vaccination of hepatitis B, regular check for hepatitis B and C infection, and receive regular treatment as soon as possible if you have hepatitis. Three, less use of insecticides and computers safer Among all chemical toxins, benzene and its derivatives are the most important myelosuppressive toxins, and its relationship with reoccurrence has been affirmed by many experimental studies. Benzene is a clear, colorless liquid that is volatile and can be inhaled through the respiratory tract or absorbed through skin contact. Long-term daily exposure to benzene is more dangerous than one large dose. In some cases, bone marrow suppression occurs months or even years after exposure to benzene has ceased. Workers engaged in dyes, paints, glues, coatings, resins, furniture, footwear, leather processing, pharmaceuticals, pesticides, fertilizers and other operations may be exposed to benzene for a long time; home renovation using paints, glues, coatings, etc., workers engaged in home renovation and people moving into new homes may become victims; farmers exposed to pesticides and fertilizers may also become victims. Try to avoid contact with chemicals and pesticides that are known to cause re-infection in life (such as paints, glues, organic solvents and pesticides, etc.). Home improvement materials should choose qualified products from regular manufacturers, and keep the air circulating after the completion of renovation and move in for at least six months. Advocate eating pollution-free vegetables. At the same time, also avoid exposure to radioactive substances, staff engaged in industries exposed to radioactive substances, need to strengthen the awareness of protection, in strict accordance with operating procedures to protect their health and prevent the occurrence of disease. Consciously reduce computer and cell phone radiation, such as reducing the time spent with the computer, the moment the cell phone is connected away from the body.