The difference between the 4-dose and 5-dose rabies vaccine is that the 4-dose vaccination method involves two doses on day 0, followed by one on day 7 and one on day 21, for a total of three doses, while the 5-dose vaccination method involves five doses on days 0, 3, 7, 14 and 28. The 4-dose method shortens the vaccination time by 7 days compared to the 5-dose method, and the 4-dose vaccine is of slightly higher quality than the 5-dose method and produces antibodies a little earlier. The 4-dose vaccine is of higher quality and produces antibodies earlier than the 5-dose method. Generally, about 7 days after the first 4-dose vaccination, the antibody (+) rate in the body can reach about 70%. For some patients with a short incubation period, this can save lives earlier, but the difference in effectiveness between the two is not significant, and both can ensure that protective antibodies are produced in the body after vaccination as prescribed by the doctor, and the patient will not suffer from rabies again within 6 months.