Leukemia-like reaction, also known as leukemia-like reaction, refers to certain factors that strongly stimulate the body to cause leukemia-like changes in the blood picture, a significant increase in peripheral blood leukocytes (>50×109/L), or the presence of abnormal immature leukocytes similar to some leukemias, but the subsequent course of the disease or autopsy confirms the absence of leukemia, and the blood picture and bone marrow picture completely return to normal after the cause is removed. The leukoid reaction is not an independent disease, and there are several common causes: i. Infection Common pathogens include bacteria, spirochetes, protozoa, viruses, etc. Leukocytic reactions caused by infection are divided into the following categories: 1. Granulocytic type: common in severe infectious diseases such as pneumonia, meningitis, diphtheria, tuberculosis (mainly cornified tuberculosis, infiltrative tuberculosis, and extra-pulmonary tuberculosis in the dissolution phase).
2, lymphocytic type: common in whooping cough, chickenpox, infectious mononucleosis, infectious lymphocytosis, tuberculosis, etc.
3, monocytic type: common in tuberculosis, cytomegalovirus infection, subacute bacterial endocarditis, etc. 4. Eosinophilic type: common in parasitic infections, such as schistosomiasis, filariasis, malaria, echinococcosis (encysticercosis), etc. Second, malignant tumors Most often seen in patients with advanced lung and gastrointestinal tract malignancies, especially after metastasis to the liver and bone marrow prone to leukemia-like reactions. Multiple myeloma, Hodgkin’s disease, melanoma osteosarcoma, breast cancer, choriocapillary epithelial carcinoma cause leukemia-like reactions are also more common. Poisoning 1, chemical factors: such as mercury, organophosphorus, benzene, nitrite and other poisoning. 2, pharmaceutical: such as arsenic agents, antipyretic and analgesic drugs, sulfonamides, adrenaline glucocorticoids, lithium salts, etc. 3.Other: eclampsia, carbon monoxide poisoning tetrachloroethane poisoning, uremia, ketoacidosis, food poisoning, etc. 4, other Acute tissue injury, acute blood loss and hemolysis, and other allergic diseases (such as exfoliative dermatitis allergic pneumonia), hyperthermia poisoning, ionizing radiation disease after splenectomy, late pregnancy, etc.