Severe nail infection is characterized by localized redness and swelling, and large areas of vesicles, yellow exudates, yellow crusts, accompanied by a certain amount of stinging pain, and in severe cases, fever, which can reach up to 39 degrees or more. In this case, it is necessary to administer levofloxacin hydrochloride injection or cefoxitin sodium injection for antibacterial and anti-infective treatment. After a few days of treatment, the redness and swelling will subside and most of the vesicles and exudates will dry up and crust over, then it can be replaced by oral amoxicillin capsules or azithromycin capsules for treatment. In the selection of topical medication can be wet application of Revnur solution twice a day, once for 20 minutes, and then apply compound polymyxin B ointment, or fusidic acid ointment for treatment.