The most widely used intermediate-acting diuretics with antihypertensive effect are mainly thiazide diuretics, such as hydrochlorothiazide, indapamide, mebenzosulfanilamide, cyclothiazide and chlorothiazide. Applied to oral drugs, the application of these drugs alone as antihypertensive drugs is not rare, the application of indapamide alone is mostly seen hydrochlorothiazide, and hydrochlorothiazide is mostly present in the preparation of the compound, the common compound of the preparation, that is, a piece of medicine with hydrochlorothiazide, but also other antihypertensive drug ingredients, such as hydrochlorothiazide and calcium antagonist combination, the two exist in a certain synergistic effect. The combination of hydrochlorothiazide and renin angiotensin II receptor antagonist together in a compound preparation, such as Ambronol, hydrochlorothiazide can further enhance the effect of renin angiotensin II receptor antagonist, and the two have a certain complementary effect, and the antihypertensive effect is better. However, in the process of single drug application, attention should be paid to the ion disorder and blood uric acid, etc. In the compound preparation, the content of hydrochlorothiazide is lower, so it is safer.