The third vaccine, generally refers to the third injection of the new coronavirus vaccine, after the third injection of the new coronavirus vaccine, the whole body pain may be caused by the adverse reaction of the vaccine, but also may be caused by upper respiratory tract infection, influenza. 1. Adverse vaccine reactions: some people may have adverse reactions after the third injection of the new coronavirus vaccine, patients will not only have generalized muscle pain, fatigue, fever and other manifestations, but also redness, swelling and pain at the site of the injection, hardness, itching and other symptoms. 2. Upper respiratory tract infection: If upper respiratory tract infection occurs after the third injection of the new coronavirus vaccine, there may be soreness of the limbs, chills, fatigue, fever, as well as nasal congestion, runny nose, sneezing, dryness of the throat, burning sensation in the throat and other manifestations. 3. Influenza: If patients develop influenza after the third vaccination, they will have generalized muscle and joint pain, chills, headache, flushing, runny nose and dry cough. It is recommended that patients with generalized pain after the third dose of the new coronavirus vaccine should consult a doctor in time, and the doctor will take appropriate measures after clarifying the cause of the disease.