Craniofacial dysmorphic syndrome may be autosomal recessive, associated with the use of certain teratogenic substances or viral infections during maternal gestation, or due to frontal lobe dysgenesis in the fifth to seventh week of fetal life. It is characterized by cephalofacial malformation, congenital cataract and hair thinning. Preventive measures: 1, try not to contact with toxic chemicals: such as organophosphorus, organochlorine, organic mercury, arsenic, benzene, carbon monoxide, heavy metal lead, cadmium, etc. 2, avoid contact with radiation: such as medical radiation, radionuclide, microwave. In the embryonic period, that is, 3-8 weeks after conception, is the most sensitive period of radiation damage to the embryo, prone to congenital defects. 3, avoid infection pathogens: there are many pathogens that cause infections in pregnant women, such as bacteria, viruses, toxoplasma, etc. The most virulent pathogens that cause intrauterine infection in the fetus are various types of viruses, especially severe malformations can occur in early pregnancy, and preterm birth can occur at the end of pregnancy. 4, careful use of drugs during pregnancy: pregnancy medication to be particularly careful, because many drugs can cause harm to the fetus. The third month of pregnancy is the formation of the fetal organs of the period of reuse, to external influences for extremely sensitive, improper use of drugs can lead to one or more malformations of the fetus. In addition, any drug that is harmful to the mother has the same toxicity to the fetus, and is not affected by the stage of pregnancy.