When various chronic kidney diseases progress to end-stage, they need to receive expensive treatments such as dialysis and transplantation, which impose a heavy burden on individuals, families and society. Therefore, how to effectively stop the progression of chronic kidney disease is the most important concern for patients with chronic kidney disease and the biggest challenge for nephrologists. In recent years, with the continuous research on the pathogenesis of chronic kidney failure, great progress has been made in slowing down the progression of kidney failure. These include dietary control and nutritional therapy, systemic and local glomerular hypertension control, hypoglycemia, hypotension, anticoagulation and antiplatelet, antioxidant and herbal therapy. In the early and middle stages of chronic renal failure, based on the treatment of the primary etiology, proven comprehensive therapeutic measures should be used as much as possible to slow down the progression of renal failure. Commonly used comprehensive treatment measures include the following: First, dietary control and nutritional therapy is the most basic measure to delay the progression of renal failure. The key is the control of protein intake and composition, other aspects include phosphorus, purine, lipid and water and salt intake control. A large number of studies have confirmed that restricting protein intake can slow the progression of renal failure, and a low-protein diet can reduce the blood urea nitrogen level of renal failure patients, reduce uremic symptoms, and also help reduce acidosis and lower blood phosphorus. At present, the low protein diet is generally advocated to ensure the intake of sufficient carbohydrates and fats to supply the body with sufficient calories (not less than 35 kcal per kg of body weight per day) on the premise of 0.6 grams of protein per kg of body weight per day, and to increase the protein intake of malnourished patients. For example, for a patient weighing 60 kg, the daily protein intake is about 36 grams. Low-protein diet can be treated with a-keto acid preparation. a-keto acid not only helps to improve the nutritional status, but also reduces the level of urea nitrogen in the body and improves the symptoms of uremia. It is worth mentioning that for chronic kidney disease, people used to think of avoiding soy products. However, in recent years, the renal protective value of soy protein has gradually received the attention of clinicians, and many studies have confirmed that the consumption of soy protein can significantly delay the deterioration of kidney function compared to the consumption of animal protein. In addition to protein intake, numerous studies have also confirmed that a low phosphorus, low purine diet and strict control of water and salt intake can help slow the progression of renal failure. Secondly, control of systemic and intra-glomerular hypertension is an effective means to slow down renal failure. Studies have found that systemic hypertension not only promotes glomerulosclerosis and aggravates renal failure, but also increases cardiovascular complications, so it must be strictly controlled. The antihypertensive treatment of chronic kidney disease generally prefers angiotensin-converting enzyme inhibitors (such as Lortin) and angiotensin II receptor antagonists (such as Coxswain), and studies have shown that these two types of drugs have a variety of effects on lowering blood pressure, reducing proteinuria, and protecting renal function. Other studies have suggested that some calcium channel blockers (e.g., Baysine et al.), may also have some renal protective effects. In addition, glucose-lowering and lipid-lowering treatments can also help delay kidney failure. Scientific studies have found that both diabetes and hyperlipidemia can induce and aggravate kidney damage, so the glycosylated hemoglobin of type 2 diabetic patients should be kept in the normal range, and the long-term use of statin lipid-lowering drugs can not only effectively control hyperlipidemia, but also reduce proteinuria and slow down the deterioration of kidney function. Deep-sea fish oil and antioxidants also have good application prospects in the treatment of renal damage with hyperlipidemia. In addition, scientific experiments and clinical observations suggest that anticoagulation and antiplatelet therapy can slow down the progression of renal failure. In chronic kidney disease, glomerular hypercoagulability and disorders of the fibrinogen/fibrinolytic enzyme system are often present, which induce or aggravate glomerulosclerosis. Therefore, anticoagulation and antiplatelet treatments such as heparin, urokinase, salvia and chuanxiongxin can protect renal function. It is worth mentioning that traditional Chinese medicine has certain efficacy on chronic renal failure. In addition to the above-mentioned Chinese medicines with anticoagulant and antiplatelet effects, a large number of studies have found that single herbs such as rhubarb and cordyceps can slow down the progression of renal failure to varying degrees, and certain compound preparations (such as renal failure nin, urotoxic clear, etc.) also have certain effects on symptom reduction and renal protection. In conclusion, the treatment of chronic kidney disease is highly specialized, and it needs to be treated on the basis of the primary cause of the disease, varying from disease to disease and from person to person, actively giving the above-mentioned comprehensive treatment measures, while avoiding the use of various nephrotoxic drugs to maximize the protection of kidney function, in order to delay the progression of kidney failure and improve the quality of life of patients with kidney disease as much as possible.