The liver is an organ without nerve, so even if the liver has active inflammation and repair, the patient will not feel any pain, and because of this, many patients delayed the opportunity to treat the clinical often encountered the review and did not review the situation led to the aggravation of the disease or even the loss of life, there was a case of a patient, about 50 years old male, farmer, has a daughter and a boy, the boy in junior high school, at first Later, when his daughter got married, he was too embarrassed to drag her down, and he was fine after several consecutive examinations, so he did not review his condition for more than a year. There are many other cases like this. Therefore, I summarize it clinically as three no’s, that is, patients with liver disease should not exert themselves, not get angry, not drink alcohol, and have regular review, the last one is very important. This way, the likelihood of missing the diagnosis will be very low.