There is no best way to treat stubborn constipation, and its treatment mainly includes dietary adjustments, medication (Mosapride, Lactulose, etc.), surgical treatment and so on. 1. Dietary management: Develop the habit of regular defecation, which can help to restore the peristaltic rhythm of gastrointestinal tract; eat more vegetables and fruits, which is good for gastrointestinal tract peristalsis. 2. Drugs: Choose mosapride, domperidone and other gastrointestinal tract dynamics, but also lactulose, polyethylene glycol dispersions, keserol, etc., acute constipation can be considered enema treatment. 3. Surgical treatment: stubborn constipation by dietary modification and drug treatment effect is not good, should be further colonoscopy, abdominal plain film, fecal imaging and other tests to exclude intestinal masses, intussusception and other diseases. If there are intestinal masses, surgery should be considered. For the treatment of persistent constipation, it is recommended to consult a doctor in time, under the guidance of a professional physician.