The vast majority of patients with gallstones who undergo gallbladder removal do not experience abnormalities. The gallbladder acts as a storage depot for bile and is capable of concentrating and storing bile so that it can be excreted in large quantities for digestion in the event of food intake. After removal of the gallbladder, the concentrating function of bile is reduced, but the body will store more bile by dilating the bile ducts, and the vast majority of them can effectively replace the function of the gallbladder, so that bile is excreted for normal digestion in the case of food intake, and will not affect the digestive function. A small percentage of patients may have poor substitution, resulting in the inability of bile to digest fatty foods completely, which can easily cause fatty diarrhea and indigestion. However, they can usually be effectively relieved with aggressive medication regulation and dietary improvement. After removal of gallbladder in patients with gallstones, due to the large amount of bile excreted without storage, long-term repeated excretion may lead to inflammation related to the colon and cause dysbiosis. It is recommended to review colonoscopy regularly to rule out the presence of colon inflammation. In addition, irregular discharge of bile may cause relaxation of the pylorus of the stomach, which may lead to bile reflux into the stomach causing gastritis and mucosal damage to the stomach, which can be improved by medication. Patients with cholecystectomy should pay attention to a diet based on low-fat and low-cholesterol foods, eat more foods rich in high-quality protein and vitamins, maintain an optimistic attitude towards life, avoid anxiety, depression and other negative emotions, and can exercise appropriately to promote the recovery of the organism.