Some middle-aged and elderly people often have small white spots on their bodies, which are medically known as senile leukoplakia. There is no significant difference between men and women, and they are round or oval in shape, ranging from a few to dozens. The area is small and not expanding. This disease is an age-related degenerative phenomenon, does not belong to the category of vitiligo and does not require treatment. The main reason is the decrease in the number of melanocytes in the skin. The disease mostly starts after 45 years of age and is more common in older people. There is no significant difference in the onset of male and female. Age-related leukoplakia, also known as idiopathic punctate hypopigmentation, is one of the manifestations of skin aging, caused by a decrease in local dopa-positive melanocytes. The disease is an age-related skin degeneration and is caused by a gradual decrease in the number of Dopa-positive melanocytes in the skin with ageing. Except for the lack of epidermal basal Dopa-positive melanocytes, the rest are not abnormal. The clinical manifestation of this disease is mainly the appearance of large rice-grain to green bean-sized round white spots on the skin of the chest, back, abdomen and other covered areas, slightly depressed, with varying numbers, often increasing with age. There are no conscious symptoms. Diagnostic points 1, the onset of middle-aged and elderly, gradually increasing with age. 2. White patches on the trunk and limbs in non-exposed areas, 2-5 mm in size, round, with clear boundaries and slightly depressed surface.