Ascending symmetric peripheral neuritis with sensory and motor deficits, decreased muscle strength, muscle soreness especially in the gastrocnemius muscle, foot drop and toe drop in some cases, and a cross-threshold gait when walking. The disease should be suspected in patients who have consumed a vitamin B1 deficient diet for more than 3 months, or who have chronic diarrhea, alcohol abuse, diuretics, and sneak attacks, and who develop cardiac enlargement, elevated venous pressure in the circulation, and edema within a short period of time without other evidence of heart disease. It may or may not be accompanied by peripheral neuritis and pellagra. The diagnosis of the disease is further confirmed by a decrease in blood transketolase activity, a decrease in heart size after vitamin B1 supplementation, disappearance of edema, and an increase in blood transketolase activity. After the diagnosis is clear, if it can be actively treated, the prognosis is better; if misdiagnosis and untimely treatment, sudden death or death from progressive heart failure can occur. Prevention: 1. Consume more brown rice, or rice with added thiamine. 2, avoid excessive intake of carbonate-containing beverages, and should not engage in strenuous activities in the summer. 3.Avoid long-term treatment with diuretics. 4. Bake or boil foods containing thiaminase, such as crab and fish.