Ascending symmetrical peripheral neuritis, sensory and motor deficits, decreased muscle strength, muscle soreness especially in the gastrocnemius muscle, foot drop and toe drop occur in some cases, walking in a cross-threshold gait. The following diseases are causes of toe drop: 1, alcoholism Alcoholism (alcoholism) refers to the mental and physical disorders caused by alcohol consumption. Alcohol dependence (alcoholic dependence) refers to a series of withdrawal symptoms that can occur once a chronic alcoholic stops drinking. In fact, alcohol-dependent people are often in a state of intoxication. The incidence of alcoholism in China is lower than that in western countries, but in recent years the incidence seems to have a tendency to increase, and should be emphasized. 2, foot fungus disease foot fungus disease that is vitamin B1 deficiency disease, vitamin B1 that is thiamine (Thiamine) is thiamine pyrophosphate (TPP) precursor, TPP is the tricarboxylic acid cycle pyruvate and α-ketoglutarate decarboxylation reaction of the important coenzymes, but also erythrocyte ketol transferase coenzymes, in addition, on the activity of the brain cells and nerve impulse conduction is also a certain relationship. Once the lack of, can cause a series of neurological and circulatory symptoms, called beriberi. 3, beriberi heart disease beriberi heart disease (beriberi heart disease) for vitamin B1 (thiamine) serious and prolonged deficiency caused by a high volume type heart disease. Peripheral arterial resistance is reduced, and the increase in cardiac output is its characteristic change.