Stroke, the dissonance on the melody of time! Time is an important dimension of life, and life is actually playing beautiful music on the melody of time, which changes with our years, seasons, day and night, rhythmically and beautifully. The melody of time, whether it is calculated by the length of life, by the seasons of the year, by the daily calculation have their own laws, the discord in the stroke also has its own laws, if we understand the background of the discord, we will reduce the chance of this occurrence, and play a more beautiful music. Stroke has different incidence rates in different age groups, with intracranial aneurysm having the highest incidence rate in youth and middle age, and ischemic cerebrovascular disease having the highest incidence rate in old age. Does stroke have its own unique note in the song of the seasons, spring, summer, autumn and winter? Summer is the high incidence season for cerebral infarction. This may be related to the high temperature in summer, the body regulates body temperature through sweating, sweating more, coupled with busy work, emotionally prone to impatience; coupled with irregular diet and exercise, easily lead to dehydration, high blood viscosity, blood transfusion to the brain is blocked to become slow, at this time, if the activity is a little larger, oxygen demand increases, forcing the heart to pump blood to supply oxygen, so whistling sharply, heartbeat accelerates, arterial blood vessels can not withstand the load, easy to induce Ischemic stroke. Therefore, in summer, attention should be paid to cooling down the temperature, and develop a good habit of drinking water regularly. Winter is the high incidence season for cerebral hemorrhage. This may be related to the low temperature and temperature fluctuation in winter, which makes sympathetic nerve excitation, peripheral vasoconstriction, long-term cold stimulation can lead to increased blood pressure, and can lead to fibrous necrosis or lipid hyaline degeneration of small arteries or deep penetrating artery walls in the brain, and the formation of small aneurysms or micro-cleft aneurysms; on the other hand, activation of the renin-angiotensin system, which increases myocardial contractility, peripheral vasoconstriction, and blood pressure, and when the blood pressure rises suddenly, it can cause vascular hemorrhage. When the blood pressure rises suddenly, it can cause blood vessel rupture. Therefore, elderly patients with hypertension should pay attention to keeping warm in winter and adjust their clothing according to the temperature immediately. Especially when the cold air suddenly attacks, the temperature drops sharply, and the blood pressure rises to a certain level, beyond the body’s ability to adapt, it is easy to induce a hemorrhagic stroke. The song of the seasons, spring, summer, autumn and winter, is a harmonious song that changes from year to year. Stroke is not one of the musical notes, nor is it popular, but it has its own unique characteristics, with its own easy places to grow, to be nourished in some neglected places, and to become a disruptor of the harmonious music. In all seasons of the year, among which winter, early spring and summer have a high incidence of stroke. January-March is the turn of winter and spring in China, and it is also the time when the traditional activities of major festivals (New Year’s Day and Spring Festival) are more concentrated, during which people are most active in their containment, living and emotional changes. Cold temperatures can cause peripheral vasoconstriction, blood pressure is prone to rise, blood pressure fluctuations, resulting in bleeding. It is especially important to pay attention to this when the Chinese New Year of the Rooster is approaching and when the temperature is falling nationwide. The devil’s time of stroke The daily time distribution of stroke: 0:00-6:00 ischemic stroke incidence is high, 6:00-12:00 hemorrhagic stroke incidence is high. 0:00-6:00 is generally in the sleep state, vagus nerve excitement, blood flow is slow, blood cells tend to gather to form clots, clots block blood vessels, resulting in poor blood flow, easy to induce The high incidence of hemorrhagic stroke between 6:00 and 12:00 may be related to the peak blood pressure at 10:00 a.m. and the fact that this is the beginning of the day, with a fast pace and many changes, and increased sympathetic excitability. The high incidence of ischemic stroke is between 04:00 and 10:00, accounting for 46.4% of the total, which is significantly different compared to other time periods. The pathogenesis of ischemic stroke may be related to the following factors: 1. Blood pressure fluctuates during the 24h day and night, generally at 01:00 to 3:00, while it rises in the early morning, especially after waking up, and reaches its highest level at 10:00. The sudden rise in blood pressure causes changes in hemodynamics, such as an increase in blood to the cerebral vascular shear stress of atherosclerosis, which leads to the occurrence of cerebral infarction, and it is reported that for every 10 mmHg increase in systolic blood pressure, the risk of stroke increases by 22%. 2, early morning arrhythmias are likely to occur, thus increasing the chance of cerebral infarction. 3, There is a 24h rhythm change in the normal balance between the thrombotic and fibrinolytic systems. The fibrinolytic system is at a low around early morning and antithrombin III levels around early morning, and blood has a tendency to coagulate in the morning time period. 4, Periodic changes in blood rheology: whole blood viscosity, plasma viscosity is at its peak from 06:00 to 10:00. 5.After waking up in the early morning, sympathetic activity increases, plasma catecholamine levels increase, and circulating adrenergic activity increases. Adrenergic vascular receptor sensitivity changes and causes vasospasm. The difference in the diurnal distribution of the onset of cerebral infarction may be due to the combined effect of the interaction of the above-mentioned factors. To be more precise, the time of day between early rising and 9 am is the high incidence of ischemic stroke, which is the devil’s time of stroke. The second peak is during sleep. One important reason is that during sleep the body excretes a lot of water through the pores, whistle and urine, and blood viscosity increases, which are natural causes of ischemic strokes. Stroke prevention, how to step on the beat of time? Life is actually playing music on the melody of time, no matter what you play, but you have to abide by the beat of time and be a good friend of time, only then can you play a beautiful music. 1, each stage of life has its own characteristics, we should do what we should do at a particular age, the road of life will be smooth; for the four seasons and every day, we should follow the biological rhythm, live regularly, step on the beat of time, so as to keep healthy and away from stroke. 2. Take appropriate preventive and nursing measures in different seasons and time periods. In hot summer, strengthen the examination and treatment of ischemic stroke patients, pay attention to cooling and timely hydration; while in cold winter, pay attention to cold and heat preservation, pay attention to the prevention and treatment of hemorrhagic stroke; strengthen the consultation and treatment of ischemic stroke from 0:00 to 6:00; strengthen the consultation and treatment of hemorrhagic stroke from 6:00 to 12:00. The diagnosis and treatment. For the circadian cycle, people need to pay attention to drinking water before bedtime and early rising to replenish excessive water loss during the night, while taking care not to over-intensify activities in the morning. 3. Human blood pressure fluctuates regularly within 24 hours. Every day, 9-11 a.m. and 3-6 p.m. is the peak time of blood pressure. For hypertensive patients, there are similar characteristics, so antihypertensive drugs should be taken half an hour to one hour before the blood pressure reaches its highest value to have the best effect. 4, the best time to take aspirin. Because the platelet newborn time at 18:00-24:00 this time period, aspirin as an inhibitor of platelet aggregation drugs, so take aspirin at this time the best. 5. Time is the brain. Brain infarction in the early onset of the most important treatment is thrombolysis and mechanical retrieval therapy, but the effective time window is limited, currently more recognized is 6 hours after the onset. Therefore, for acute stroke, we should pay attention to early detection and early treatment to maximize the recovery of neural tissue. The melodies of time are the beautiful notes of nature and are self-contained. It is only when we as individuals recognize these melodies that we can integrate organically and become a harmonious note in the melody of time, so that the dissonance in the melody of time, stroke, is far away from us and we can enjoy the beautiful music.