Ruling out AIDS is conditional on a negative combined antigen/antibody test and a negative virologic test. When considering the possibility of acute or early HIV infection, the most sensitive diagnostic test available, such as HIV virologic (viral load) testing, may be performed. In addition to the HIV viral load test, a combined antigen/antibody test is performed. A negative antigen/antibody panel and a negative virologic test are highly suggestive that HIV infection has not been acquired. If HIV infection is suspected from a very recent high-risk exposure, it is important to retest in 1-2 weeks, especially if there are symptoms of acute HIV infection. AIDS is mainly through blood transmission, sexual contact transmission, mother-to-child vertical transmission, with high-risk behavior, must pay attention to the exclusion of AIDS, exclusion of AIDS must go to the hospital to test the relevant indicators. HIV high-risk behavior should be timely oral blocking drugs for treatment, oral drugs or need to test HIV antibodies.