The duration of application of zoledronic acid varies according to the type of disease treated and cannot be generalized. Zoledronic acid is a bisphosphonate drug, which mainly inhibits the activity of osteoclasts in the body. If zoledronic acid is used in the treatment of osteoporosis, it can be used once a year for 3 years. After the injection of zoledronic acid, the bone destruction in the body can be relieved to some extent, and then the exogenous calcium supplementation can be used to promote bone reconstruction and anti-osteoporosis. If it is used for the treatment of complications related to malignant bone tumors, it may be used once in 3-4 weeks, and the frequency of use should be decided according to the condition. In conclusion, zoledronic acid is more effective and easy to use, and is often used in women with osteoporosis during menopause, as well as in elderly people with osteoporosis. However, after the application of this drug, it may affect the liver and kidney function and needs to be observed in the hospital.