Nocturnal feeding syndrome was first reported in 1955, but did not receive attention until 1990. 2/3 of patients with nocturnal-associated eating disorders are female and typically begin in early adulthood, although it can range from early childhood to adulthood. Most patients eventually enter nocturnal binge eating. Clinically, multiple nocturnal awakenings and eating and drinking are seen. There is at least one awakening per night, an impulsive search for food, and a full feeding before falling asleep again. The motivation to search for food is defined as an urgent search for food and rapid swallowing to eat without actually being hungry. The patient was fully awake at the time and could clearly recall the above events in the morning. Despite the lack of hunger, the patient feels compelled to eat and prefers high-calorie foods. Macaroni and meatballs are often eaten with empty hands. Strange behaviors, such as eating strange mixtures o or non-nutritious substances, also occur. Lack of morning appetite and abdominal expansion, overweight, and discouragement are common. 1/3 of patients see injuries such as lacerations and burns during preparation and eating. Rarely drink alcohol and do not cleanse. Morning anorexia, over-eating at night and insomnia may be seen. Neuroendocrine studies have shown that nocturnal feeders have significantly lower nocturnal elevated levels of plasma melatonin and leptin and significantly higher plasma cortisol levels. Polysomnographic studies found lower levels of sleep efficiency, increased wakefulness, and nocturnal feeding periods associated with non-REM sleep. The feeding latency, i.e. the interval between awakening and the onset of chewing, was shorter than 30 seconds. Most commonly associated with sleep walking disorder, also seen in restless legs syndrome, obstructive sleep apnea, episodic sleeping sickness, after alcohol, opiate and cocaine abuse withdrawal, smoking cessation, stress especially separation anxiety, medication, multiple organic and neurological disorders (e.g. migraine, autoimmune hepatitis, encephalitis). Daytime eating disorders are very different from sleep-related eating disorders. The main focus is on treating the underlying sleep disorder. Available dopaminergic drugs, benzodiazepines, and opioids are effective as monotherapy or in combination. Fluoxetine hydrochloride and bupropion are also available. Psychotherapy and behavioral therapy are not effective.