Syphilis only the first injection symptoms significantly relieved, mainly related to the patient’s condition is milder, better health, timely treatment and other factors. Syphilis is a chronic, systemic sexually transmitted disease caused by syphilis spirochete infection, mainly through sexual contact, mother and child, blood and other ways of transmission. After diagnosis, patients preferred penicillin treatment, such as benzylpenicillin, procaine penicillin, etc., under the guidance of doctors to kill the syphilis spirochete, and if they are allergic to penicillin, they need to change to other drugs for treatment. For milder conditions or patients with good health, early detection and early treatment, after the first injection, there is often a significant relief of symptoms, this situation also need to continue to follow the doctor’s instructions for reasonable treatment and regular follow-up. It is recommended that patients suffering from syphilis, pay attention to avoid sexual intercourse, avoid cross use of personal belongings with others, and usually pay attention to supplemental nutrition to enhance immunity.