Only the total bilirubin is high or not can not be generalized, if it is due to alcoholism and other physiological factors generally does not matter, if it is due to liver and gallbladder disease and other pathologic factors should be paid attention to. 1. Physiological factors: mainly include staying up late, tiredness, excessive exercise, taking drugs, etc., will make the liver cell transient damage, or red blood cells have a slight hemolysis, will lead to total bilirubin increased. This is generally a physiological factor, after improving living habits, can gradually return to normal, usually does not matter. 2. Pathological factors: when the patient has viral hepatitis, fatty liver, cirrhosis, hepatocellular carcinoma, bile duct stones and other liver and gallbladder diseases, or hemolytic anemia and other hemolytic diseases, will lead to elevated total bilirubin, the patient is usually accompanied by jaundice, that is, the skin and mucous membranes, yellow eyes, yellow urine deepening, then it is more important to pay attention to. Patients with high total bilirubin are advised to consult a doctor in time to identify the cause of the disease and carry out targeted treatment to avoid delaying the condition.