In clinical work, we often encounter a lot of patients with positive tests for mycoplasma and chlamydia, some of which are found during physical examinations, and some of which are found when the wife has a vaginal infection or urethritis and asks the husband to go for a test. Whenever the results come out, the patient will have many questions, asking if this is a sexually transmitted disease, if it was transmitted to him by the other party, or how did he get this disease, etc. Here I would like to explain my point of view on the issue of whether it is necessary to treat patients who are found to be positive for mycoplasma and chlamydia and who do not have any symptoms or discomfort of their own. In fact, this issue is debated in the medical community itself, some feel the need for treatment, it must be turned negative, and some feel that there are no symptoms, discomfort, can not be treated, while I prefer the latter. Mycoplasma and Chlamydia infections mainly cause non-gonococcal urethritis, which is mainly transmitted through sexual intercourse, and a few can also be indirectly transmitted. It’s mostly seen in the young sexually active period, especially after impure intercourse. But for patients who are found to be positive for mycoplasma and chlamydia without any symptoms or discomfort on physical examination, is it necessary to treat them? Epidemiological surveys have shown that Mycoplasma solium can be isolated from 34% of normal men, and in some studies abroad, Chlamydia trachomatis was isolated from 11% of asymptomatic soldiers, 11% of asymptomatic men in urban emergency departments, and 7% of asymptomatic college students. The above figures show that normal people are capable of having mycoplasma and chlamydia parasites. In fact, there are a large number of microorganisms parasitic in the human body, many of which are still disease-causing microorganisms. But many of us are still healthy and normal because we have a good immune system and some beneficial flora that can maintain the “flora balance” between these microorganisms. When our resistance decreases and our immunity is compromised, these disease-causing microorganisms can take advantage of the situation and cause disease. Mycoplasma and Chlamydia cause non-gonococcal urethritis mainly because of the high frequency of sexual intercourse or masturbation in many young people, leaving the sexual organs in a state of chronic congestion. The epithelium of the urethra and genital tract is less resistant to pathogens, which can easily lead to mycoplasma and chlamydia infections and non-gonococcal urethritis. Infection with mycoplasma and chlamydia, or what we call non-gonococcal urethritis, often manifests as urethral discomfort, itching, burning sensation or stinging, urethral redness and swelling, and low, thin, mucous or mucopurulent urethral discharge. Longer periods without urination (e.g., morning rise) may overflow a small amount of thin discharge from the external urethral opening. Sometimes it only manifests itself as morning scabs sealing the urethral orifice or contaminating the underwear. Sometimes the patient has symptoms without discharge, or may have discharge without symptoms.