Generally speaking, not sleeping overnight does not have much effect on the next day’s vaccination. If there are no uncomfortable symptoms or only slight drowsiness or fatigue, and there are no other diseases, it is usually possible to get the vaccination. However, if you have more serious symptoms such as headache, nausea, palpitations, shortness of breath, or if you have a medical condition, it is recommended that you wait until your health condition returns to normal. Contraindicated groups of people for the new crown vaccine usually include mainly people with thrombocytopenia or bleeding disorders such as purpura; people with convulsions, epilepsy, encephalopathy and other progressive neurological diseases and a history of psychiatric disorders; people with congenital or acquired immunodeficiency, HIV infection, lymphoma, leukemia or other autoimmune diseases. In addition, if there is a fever, or if you are in a period of acute attack of various acute diseases as well as chronic diseases, such as cold, upper and lower respiratory infections, infectious diarrhea, etc., it is recommended to suspend vaccination and consider it after complete recovery. People who have had serious adverse reactions after vaccination are also not recommended to receive the New Crown vaccine. Therefore, whether or not the vaccine can be administered after a night without sleep will depend on the situation after consulting a professional. It is important to take personal protective measures when receiving the vaccine, including wearing a mask, washing hands regularly, and maintaining a social distance. Do not take a shower on the day of the vaccination. After the vaccination, you should not drink alcohol, avoid spicy and irritating food, and avoid strenuous exercise in the near future.