Exercise, weight loss and obesity Some studies have shown that people who consistently engage in light physical activity and exercise have a 35% reduction in the incidence of cerebral cardiovascular disease, diabetes, cancer, and progeria than those who do not participate in exercise or who exercise occasionally and vigorously, and their life expectancy will be significantly longer by 4 to 6 years. In overweight individuals, even a mild weight loss (equivalent to 5-10% of initial body weight) can cause significant improvements in blood pressure, blood lipids and glucose tolerance and or insulin resistance. Reduce mental stress and maintain a balanced psychology Long-term mental stress and depression are associated with increased plasma adrenaline concentrations and chronic sympathetic arousal. Sympathetic excitation and elevated plasma catecholamine levels can lead to platelet activation, macrophage activation, upregulation of inflammatory molecule expression, resulting in abnormal vascular endothelial function and the development of hypertension.