Chronic atrophic gastritis C3 suggests mucosal atrophy to the cardia and may be associated with biological, immunologic, physical, chemical, and other factors. Atrophic gastritis is categorized as open as well as closed on gastroscopy, and C refers to closed. Depending on the extent of atrophic gastritis, it is categorized as C1, C2, and C3. If the atrophy is limited to the gastric antrum, it is called C1; up to the angle of the stomach, the body of the stomach, and the lesser curvature of the body of the stomach, it is called C2, and if it reaches the cardia, it is called C3. 1. Biological factors: Helicobacter pylori infection may cause this disease. 2. Immune factors: autoimmune reaction may cause this disease. 3. Physical factors: Long-term consumption of strong tea, strong alcohol, coffee, too hot, too cold or too rough food can lead to repeated damage to the gastric mucosa. 4. Chemical factors: long-term use of aspirin and other non-steroidal anti-inflammatory drugs, long-term smoking and other reasons can lead. 5. Other factors: may be related to age and other factors. There are many other causes of chronic atrophic gastritis c3, it is recommended to clarify the cause under the guidance of a doctor, to avoid blindly using their own medications.