Localized twitching of the lips can be attributed to the following causes: 1. Patients with previous cerebral infarction or cerebral hemorrhage who have localized twitching of the lips are considered to have epilepsy, which can be clarified by video EEG or dynamic EEG. 2. Patients with extrapyramidal diseases may have paroxysmal twitching of the lips, accompanied by eyebrow squeezing. 3. 4. Some patients with long-term mental tension and excessive stress may also have localized orofacial twitching.