Sweaty hands and feet may be caused by endocrine disorders, palmoplantar keratosis and neurological diseases, which require differential diagnosis according to different causes and different treatment measures, including lifestyle adjustment and medication to relieve symptoms. 1, endocrine disorders: long-term mental tension, anxiety and excessive stress cause endocrine disorders, resulting in the loss of balance in the body’s hormone levels, causing the body’s metabolic function to decline, resulting in sweating that cannot be discharged through urine. The sweat can not be discharged through the urine, resulting in more sweating on the hands and feet, you can adjust your lifestyle, adjust your state of mind, relax, pay attention to rest to relieve symptoms, if necessary, you can also follow medical advice to take medication; 2, palmoplantar keratosis: belongs to the genetic skin disease, characterized by hyperkeratosis of the palms and feet, also prone to sweating performance. You can use topical compound lactic acid cream or salicylic acid cream to coat the skin of the hands and feet as prescribed by the doctor, which will help in the overall recovery, but it should be noted that this disease is prone to recurrence, and moisturizers such as hyaluronic acid gel can be applied to the hands and feet for a long time, which can reduce the recurrence rate to a certain extent; 3, abnormalities of the nervous system: such as concussion, pituitary hyperfunction, hemiplegia and other autonomic nerve damage or dysfunction, causing excessive sweating of the hands and feet. You should actively treat the original disease to relieve the symptoms, such as hyperpituitary gland function can generally relieve the symptoms by way of surgery. If the sweating is serious, you can apply powder on your hands and feet to absorb the sweat and keep your hands and feet dry. You can increase your physical activity to enhance your physical fitness, avoid eating too much spicy and stimulating food, and quit smoking and drinking.