As the onset of chronic renal failure is found to be very slow in the clinical process, most patients are difficult to find the existence of the disease after the onset of the disease, where the kidney failure seriously affects the health of the kidneys, if the disease appears we should do a good job of targeted treatment early, to seize the best time for treatment, to get rid of the disease early, we will talk about the typical performance of chronic renal failure in detail below. Patients with chronic renal failure have a variety of symptoms and manifestations in the clinic, mainly caused by the retention of a variety of toxins and metabolites, so it will involve all systems at the same time the corresponding symptoms. 1. Digestive system: The main manifestations of patients after the onset of the disease include anorexia, nausea, vomiting, diarrhea, and in some patients, the mouth smells like urine and the digestive tract may bleed as a result. 2, mental nervous system: patients mainly show mental depression, memory loss, dizziness, headache, insomnia, numbness of the limbs, some patients will also appear itchy “restless legs” syndrome, some patients can also have abnormal sense of smell, urination difficulties, etc., serious patients can also be coma. 3, cardiovascular system: after the onset of cardiovascular system involvement, patients often have symptoms of hypertension, palpitations, heart failure, shortness of breath, inability to lie down, arrhythmia, serious patients may appear pericardial effusion, and even serious patients may also occur pericardial tamponade. 4. Hematopoietic system: The main typical symptoms of patients show severe anemia, and patients in advanced stages may also have a tendency to bleed from various organs. 5, the respiratory system: patients self-perception of the gas whistled with the smell of urine, but also can appear metabolic acidosis of the whistle. 6, skin manifestations: the patient’s skin will become lusterless, flaking, melanin deposition, itching, some patients can also have edema, skin infection after the onset of the disease. 7, skeletal system: Some patients can show typical symptoms of renal bone disease, showing bone and joint pain. 8.Immune system hypofunction: It is easy to develop various infections, including bronchitis, skin boils, pneumonia, pleurisy, urinary tract infection, etc. 9. Metabolic disorders: Typical symptoms include imbalance of water, electrolytes and acid-base balance, which can lead to edema or dehydration and hand and foot convulsions in severe cases. As the patient will appear in the body of calcium, phosphorus metabolism disorders, vitamin D metabolism disorders, and also lead to the patient’s gonadal dysfunction, female patients will also show irregular menstruation, or even serious menopause, men in the onset of the main performance of the loss of sexual desire. Therefore, the symptoms of this disease are very harmful and require patients to pay great attention to timely treatment.