It is possible that medication may be required after ablation of malignant thyroid nodules, depending on the condition. In order to prevent or inhibit the metastasis and recurrence of the disease after thyroid malignant nodule ablation, patients may be required to take levothyroxine and thyroxine tablets. Besides, if pain symptoms occur after thyroid ablation, mild pain may be treated with ibuprofen for pain relief; severe pain may be treated with tramadol. Moreover, if the area of thyroid gland destroyed during ablation of malignant thyroid nodules is too large and hypothyroidism occurs after the procedure, levothyroxine should be taken under doctor’s supervision to control the thyroid hormone level within a reasonable range. Patients after ablation of malignant thyroid nodules should cooperate with the doctor for active treatment and regular review after the operation.