Gallstones are one of the most common diseases in clinical practice. Generally speaking, if the stones do not block the bile ducts, patients often do not experience significant abdominal distension and abdominal pain. Once the stone becomes lodged, it will cause spasmodic pain in the bile duct, obstructive jaundice, nausea, vomiting and other common clinical manifestations. What drugs are available for the clinical treatment of gallstones, and how is the best way to treat them? The root cause of gallstones, in addition to the patient’s own stone-prone body, is the poor excretion of bile, resulting in excessive accumulation of bile in the bile ducts or gallbladder, which can induce the precipitation of stone crystals. Once the stone formation is complicated by infection, the patient will suffer from more serious complications such as biliary stasis, impaired liver function and infection. Therefore, the treatment of gallstones is mainly three-fold, on the one hand, drugs to control infection in the body, on the other hand, drugs to promote bile excretion, and on the other hand, drugs to protect the liver. These drugs can promote the contraction of the gallbladder to strengthen the contraction function of the gallbladder, so that the accumulated bile can be excreted as soon as possible to avoid the formation of stones in the gallbladder. Second, the infection caused by gallstones, the main clinical application of cefamandole, cefmetazole, ceftazidime, cefoperazodone tazobactam, piperacillin tazobactam, ornidazole and other drugs for anti-infective treatment, timely anti-infective treatment can avoid serious progressive aggravation. Third, the main drugs for liver protection treatment are magnesium isoglycyrrhizate, reduced glutathione, polyenyl phosphatidylcholine, menthyl ornithine, etc., which can make the damaged liver cells return to normal as soon as possible. The treatment of gallstones, clinically surgical removal of gallbladder and stones is the most thorough treatment program, drug treatment is only to treat the symptoms but not the root cause, easy to recur.