Hepatitis B antiviral drugs taken is not unable to stop, if the patient serum test is negative, generally can combine their own situation, under the guidance of the doctor to stop taking drugs. Hepatitis B is mainly a viral hepatitis caused by hepatitis B virus infection, due to the hepatitis B virus has a certain degree of contagiousness and replication, patients once diagnosed, need to actively take antiviral drugs, so as to control the development of the virus and improve the prognosis. If patients can effectively inhibit the development of the virus after treatment with antiviral drugs and achieve the elimination of the virus, and serum examination, the body serum viral antigen is negative, can be combined with their own situation, stop taking drugs as prescribed by the doctor. However, if the patient has cirrhosis and needs to take drugs for a long time, or the virus is still in the stage of replication, the patient should strictly take antiviral drugs as prescribed by the doctor, so as to effectively improve the symptoms of the disease and prolong the patient’s survival time. Therefore, whether patients with hepatitis B virus infection need to continue to take medication should take into account their own situation and ask their doctor’s advice.