If the urine routine is normal and the creatinine is high, it is usually necessary to identify the cause of the disease and target treatment. If the creatinine is elevated due to physiological reasons, such as high muscle content or eating more meat, the creatinine may return to normal after adjusting the lifestyle habits, and no special treatment is needed. If the creatinine is elevated due to pathologic reasons such as acute kidney injury or chronic renal insufficiency, it needs to be treated according to the cause. 1. Physiological reasons: some patients’ creatinine elevation may be caused by their high muscle content, or eating more meat and exercising more, if there is no abnormality in urine routine and ultrasound of urinary system, creatinine may return to normal after adjusting the lifestyle, and there is no need for special treatment. 2. Pathologic causes: (1) Acute kidney injury: acute kidney injury caused by various reasons may have normal urine routine and high creatinine. It needs to be treated according to the cause. For example, drug-induced acute kidney injury needs to stop using relevant drugs, infection causes need to apply antibiotics and other drugs for treatment, and insufficient renal blood flow caused by excessive blood loss needs to be rehydrated and other related treatments. (2) Chronic renal insufficiency: such as hypertensive renal damage, gouty nephropathy may appear normal urine routine and high creatinine. Actively control the blood pressure, blood uric acid level, can use drugs to reduce creatinine, such as medicinal charcoal tablets, Haikun Kidney Xi and other symptomatic treatment. If patients find that blood creatinine is elevated, it is recommended to go to regular hospitals in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.