Long-term infertility is generally divided into female factors and male factors. Female factors are generally divided into the following: 1. uterine and pelvic factors, such as pelvic adhesions, uterine adhesions, etc., such as someone who has had an abortion, had invasive surgery, incomplete post-operative or couple life is not very careful, not very hygienic will cause infection, after the infection will cause pH changes in the uterine cavity, sperm vitality will decline, which will eventually affect the spermatozoa. This will eventually affect the vitality of the sperm and cause sperm-egg union disorders leading to infertility; 2. Ovulation disorders, such as premature ovarian failure in older patients as they grow older. For example, in older patients, the ovaries will fail prematurely as they age. The ovarian reserve is not good and will produce non-ovulation or small follicle ovulation, so that there are no normal eggs to fertilize with sperm. Young patients with polycystic ovary syndrome are also unable to ovulate normally, so this can also lead to infertility; 3. Immunological infertility, some female patients will produce some antibodies, such as anti-sperm antibodies, which can reject the invasion of sperm, equivalent to killing sperm, which can also lead to infertility; 4. Unknown causes, at present, there are many women in the clinic who have a reduced ability to conceive, but also do not check where the problem lies. At present, the cause is not known clinically, so it is collectively called unexplained infertility. For long-term infertility caused by male factors, sexual dysfunction is the first consideration, such as retrograde ejaculation and erectile dysfunction. There are also oligospermia, weak spermia, teratozoospermia, where the quality of semen is very poor and the amount of sperm united with the egg is not reached, resulting in less hyaluronidase secretion and inability to complete normal fertilization, which in turn leads to infertility.