The stress response refers to the systemic reaction of the body when it is stimulated by internal or external environment, including physical or psychological stimuli, which can cause stress response as long as it reaches a certain intensity. For example, serious diseases, infections, surgical trauma, high or low environmental temperatures, etc. Stress is the body’s experimental and protective response to the external environment. Hormonal changes under stress and the effects on blood glucose include the following: a. Increased sympathetic excitability and increased secretion of catecholamines, including epinephrine and norepinephrine, which can reduce insulin secretion and increase glucagon secretion, thus causing an increase in blood glucose. Second, the secretion of glucocorticoids increases under stress, and glucocorticoids can cause hepatic glycogenolysis and gluconeogenesis, resulting in an increase in blood glucose. Third, the body also decreases the sensitivity of peripheral tissues to insulin under stress conditions, so the increase in secretion of various insulin antagonistic hormones under stress conditions and the decrease in the role of insulin can lead to an increase in blood glucose and even the occurrence of diabetes. Acute hyperglycemia, blood glucose will return to normal after the stress is lifted. Therefore, blood glucose under stressful conditions is not used as a diagnostic criterion for diabetes, and blood glucose should be re-monitored after the stress is lifted to assess the diagnosis of diabetes.