Cerebral palsy is a group of persistent central motor and postural developmental disorders and activity limitation syndromes that result from non-progressive brain damage in the developing fetus or infant. The motor deficits of cerebral palsy are often accompanied by sensory, perceptual, cognitive, communication, and behavioral deficits, as well as epilepsy and secondary musculoskeletal and skeletal problems. The etiology is not yet clear and may be related to genetic, chemical and other factors affecting brain development, as well as associated high-risk factors such as low birth weight, prematurity, history of birth asphyxia and jaundice. (1) Prenatal factors: ① Infections during pregnancy are the cause of fetal neurodevelopmental abnormalities, including cytomegalovirus, toxoplasma, rubella virus, herpes simplex virus, EBV, etc. ②Maternal factors: including the mother’s use of drugs in early pregnancy; mother’s history of bad pregnancy and delivery, such as the history of stillbirth, premature birth, habitual abortion, etc.; mother’s long-term exposure to an environment unfavorable to her health during pregnancy, such as industrial pollution, etc.; mother’s bad habits, such as drug use, smoking, alcohol abuse, etc.; mother’s epilepsy during pregnancy, or hyperthyroidism before pregnancy, etc.; mother’s malnutrition during pregnancy, anemia, or The mother may suffer from malnutrition, anemia, or microelements such as folic acid, zinc, copper and manganese in early pregnancy, which may hinder the maturation of the fetal brain and other tissues and organs and further damage the central nervous system, resulting in cerebral palsy. ③Multiple pregnancies: In multiple pregnancies, the placenta is relatively underactive, and the placenta does not provide enough nutrients to the fetus, and colleagues are also prone to combined hypertensive disorders during pregnancy, excessive amniotic fluid, premature rupture of membranes, etc., which may cause fetal dysplasia and premature delivery, and neurological and respiratory circulatory disorders after birth. Genetic factors: Recent studies at home and abroad have shown that genetic factors play an important role in the etiology of cerebral palsy. Some children with cerebral palsy may have a family history of genetic disorders, such as cerebral palsy, mental retardation or congenital malformations in the maternal and paternal family of the same or previous generations. The relationship between cerebral palsy and genetics is not yet fully understood, but in June 2015 Nature communications published the detection of variants in several genetic loci in children with cerebral palsy, considering that cerebral palsy may be associated with genetic mutations or inheritance, but the evidence is not yet sufficient. Intrauterine infection during pregnancy, preterm abortion, adverse environmental exposure, or exposure to toxicants are all risk factors for cerebral palsy. (2) Intrapartum factors: Prematurity and low birth weight infants, as well as severe asphyxia during delivery for various reasons, are important causes of cerebral palsy. (3) Postnatal factors: neonatal hypoxic-ischemic encephalopathy/neonatal hyperbilirubinemia/neonatal intracranial hemorrhage, neonatal intracranial infection, etc. can cause cerebral palsy. Since so many factors can cause cerebral palsy, is it possible to find out through maternal examination during pregnancy? Actually, there is no sufficient evidence that cerebral palsy can be detected through maternal examination. However, structural abnormalities of the brain or central nervous system can be detected through fetal ultrasound and fetal MRI, and some genetic metabolic diseases can be detected through chromosomal and genetic testing techniques.