Although there is not much medical evidence on fertility during antiviral treatment in men with hepatitis B, the situation is much simpler than in women. For planned conceptions, you can either start with antiviral therapy, wait for a sustained treatment response, and then conceive after a period of discontinuation, or conceive before antiviral therapy, followed by antiviral therapy. 2.For the planned conception of those who are receiving antiviral therapy, interferon must be stopped for more than 3 months before conception; while after nucleoside analog therapy, for those with milder disease, the drug can be stopped for more than 2 weeks and then conception can be carried out; for those with more severe disease who cannot stop the drug, the drug can be replaced by LMV or TDF or LDT for a period of time and then conception can be carried out. 3. For male unwanted conceptions during oral nucleoside analogues, the woman can continue the pregnancy after full communication and close observation; however, for male unwanted conceptions during interferon treatment, the safety is unknown and the woman is advised to terminate the pregnancy after full informed communication. Regarding pregnancy and anti-HBV treatment, especially the safety of anti-HBV on pregnancy, in the context of traditional family values in China, clinicians are not only faced with a patient’s disease problem, but also with a social problem from a family, or even a family. For the serious medical and social problem of anti-HBV treatment in pregnancy, more evidence needs to be accumulated on how to minimize the risks and maximize the benefits. For families desperate for a child, the decision should remain with the patient and their family, after fully informing them of the benefits and risks and weighing the pros and cons adequately. “There is no road in the world, but the more people walk, the more it becomes a road”. We can only break through this forbidden zone, make progress and make a difference if we continue to accumulate more evidence of interrogative medicine.