The so-called failed hepatitis B vaccination is the failure to produce protective antibodies (anti-HBs) in the body after vaccination, and these people are still at risk of contracting hepatitis B virus (HBV), especially in environments where there is hepatitis B exposure. The causes of hepatitis B vaccination failure are not entirely clear. The first thing to rule out is whether there is a problem with the hepatitis B vaccine and whether the vaccination was done improperly, in addition to the low or no immune response to the hepatitis B vaccine itself. There are the following four ways to remedy the situation. 1. Re-vaccinate and increase the vaccination dose. If only 10 micrograms were used in the original vaccination, increase the dose to 15 to 20 micrograms this time. For “high-risk groups” such as medical personnel engaged in hemodialysis and dental personnel, the vaccination dose can be 40 micrograms per injection. 2. Change the hepatitis B vaccine of different manufacturers when revaccinating. The vaccination should be given 3 times (according to the 0, 1, 6 program). 3.A booster hepatitis B vaccine containing 60 micrograms per vaccine has been newly produced in China. Anyone whose original vaccination failed can apply this vaccine and only one injection is needed. 4.Give some immune booster such as Yu Ping Feng granules and splenamine-based oral solution at the same time of vaccination.