Cystic thyroid nodules with calcification are generally considered benign nodules, mostly considered to be nodular goiter with cystic degeneration. Most of the cyst walls will form calcified foci due to inflammation and necrotic tissue absorption. According to the description of the ultrasound, attention should be paid to the calcification of seminal salt-like calcification or sand-like calcification, as well as to the calcification of hypoechoic nodules accompanied by cystic nodules. If the nodule is purely cystic and there is no hypoechoic mass in the cyst, there is usually no need to worry too much and regular review is sufficient. If the cyst is relatively large and accompanied by calcification, sometimes the calcification cannot be punctured, it is difficult to clarify the nature and may be accompanied by symptoms of local pressure, surgery can be considered, the surgery is usually done unilateral glandular lobectomy, and the trauma is not very big.