There is no so-called “fastest way to stop itching” for the itching symptoms of HFMD, patients need to relieve itching symptoms through general treatment, medication and other ways, but the specific efficacy varies from person to person. 1. General treatment: attention should be paid to the protection of the affected area, keep the skin clean and dry. Drink plenty of water, have a regular routine, and get enough sleep; those with oral damage should pay attention to oral hygiene and consult a dentist. 2. Medication (1) Local medication: when the blisters are not broken, local glycerine lotion can be applied to astringent and itch-relieving treatment. After herpes rupture, it is necessary to protect the wound and prevent infection. (2) systemic drug therapy: usually symptomatic treatment, severe itching can be prescribed oral antihistamines such as loratadine treatment, fever patients can take oral ibuprofen and other non-steroidal anti-inflammatory drugs to reduce fever treatment. It is recommended that patients with hand, foot and mouth should go to a regular hospital in time, and standardize the use of medication under the guidance of the doctor.